Abstract 'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every
day, thousands of DNA damaging events take place in each cell of our body, but efficient …

Proliferating cell nuclear antigen (PCNA), a cell cycle marker protein, is well known as a
DNA sliding clamp for DNA polymerase delta and as an essential component for eukaryotic …

Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …

Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …

Abstract Flap EndoNuclease-1 (FEN-1) and the processivity factor proliferating cell nuclear
antigen (PCNA) are central to DNA replication and repair. To clarify the molecular basis of …

Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …

Toward the end of the 20th and beginning of the 21st centuries, clever in vitro biochemical
complementation experiments and genetic screens from the laboratories of Xiaodong Wang …

Flap endonuclease‐1 (FEN1) is a key enzyme for maintaining genomic stability and
replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its …

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …

The careful orchestration of cellular events such as DNA replication, repair, and segregation
is essential for equal distribution of the duplicated genome into two daughter cells. To …