The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis
S Lapehn, AG Paquette - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
Omics approaches to study formation and function of human placental syncytiotrophoblast
A Jaremek, MJ Jeyarajah, G Jaju Bhattad… - Frontiers in Cell and …, 2021 - frontiersin.org
Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …
exchange of nutrients and gases between maternal and fetal blood and produces hormones …
[HTML][HTML] Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology …
Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …
Sex at the interface: the origin and impact of sex differences in the developing human placenta
The fetal placenta is a source of hormones and immune factors that play a vital role in
maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic …
maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic …
[HTML][HTML] Significance of the placental barrier in antenatal viral infections
The placenta provides a significant physical and physiological barrier to prevent fetal
infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to …
infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to …
Microfluidics facilitates the development of single-cell RNA sequencing
Y Pan, W Cao, Y Mu, Q Zhu - Biosensors, 2022 - mdpi.com
Single-cell RNA sequencing (scRNA-seq) technology provides a powerful tool for
understanding complex biosystems at the single-cell and single-molecule level. The past …
understanding complex biosystems at the single-cell and single-molecule level. The past …
Placental contribution to neonatal encephalopathy
AA Penn, P Wintermark, LF Chalak, J Armstrong… - Seminars in Fetal and …, 2021 - Elsevier
Placental assessment, although currently underused, can inform our understanding of the
etiology and timing of Neonatal Encephalopathy (NE). We review our current understanding …
etiology and timing of Neonatal Encephalopathy (NE). We review our current understanding …
Oxidative stress on vessels at the maternal-fetal interface for female reproductive system disorders: Update
C Zhang, Y Guo, Y Yang, Z Du, Y Fan… - Frontiers in …, 2023 - frontiersin.org
Considerable evidence shows that oxidative stress exists in the pathophysiological process
of female reproductive system diseases. At present, there have been many studies on …
of female reproductive system diseases. At present, there have been many studies on …
Coordinated expressional landscape of the human placental miRNome and transcriptome
R Inno, T Kikas, K Lillepea, M Laan - Frontiers in Cell and …, 2021 - frontiersin.org
Placenta is a unique organ that serves its own function, and contributes to maternal
gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all …
gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all …
Placental transcriptome profiling in subtypes of diabetic pregnancies is strongly confounded by fetal sex
SM Kedziora, B Obermayer, M Sugulle, F Herse… - International Journal of …, 2022 - mdpi.com
The placenta is a temporary organ with a unique structure and function to ensure healthy
fetal development. Placental dysfunction is involved in pre-eclampsia (PE), fetal growth …
fetal development. Placental dysfunction is involved in pre-eclampsia (PE), fetal growth …