Molecular and evolutionary processes generating variation in gene expression

MS Hill, P Vande Zande, PJ Wittkopp - Nature Reviews Genetics, 2021 - nature.com
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Evolution of gene duplication in plants

N Panchy, M Lehti-Shiu, SH Shiu - Plant physiology, 2016 - academic.oup.com
Ancient duplication events and a high rate of retention of extant pairs of duplicate genes
have contributed to an abundance of duplicate genes in plant genomes. These duplicates …

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016 - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

[HTML][HTML] Heavy metal tolerance in plants: role of transcriptomics, proteomics, metabolomics, and ionomics

S Singh, P Parihar, R Singh, VP Singh… - Frontiers in plant …, 2016 - frontiersin.org
Heavy metal contamination of soil and water causing toxicity/stress has become one
important constraint to crop productivity and quality. This situation has further worsened by …

[HTML][HTML] Lactose intolerance in adults: biological mechanism and dietary management

Y Deng, B Misselwitz, N Dai, M Fox - Nutrients, 2015 - mdpi.com
Lactose intolerance related to primary or secondary lactase deficiency is characterized by
abdominal pain and distension, borborygmi, flatus, and diarrhea induced by lactose in dairy …

Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

Role of secondary metabolites and brassinosteroids in plant defense against environmental stresses

A Bartwal, R Mall, P Lohani, SK Guru… - Journal of plant growth …, 2013 - Springer
Being sessile, plants are subjected to a diverse array of environmental stresses during their
life span. Exposure of plants to environmental stresses results in the generation of reactive …

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

LJ Holt, BB Tuch, J Villén, AD Johnson, SP Gygi… - Science, 2009 - science.org
To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and
conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase …

Transposable elements and the evolution of regulatory networks

C Feschotte - Nature Reviews Genetics, 2008 - nature.com
The control and coordination of eukaryotic gene expression rely on transcriptional and post-
transcriptional regulatory networks. Although progress has been made in mapping the …