Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …
The molecular mechanism of mechanotransduction in vascular homeostasis and disease
Y Yamashiro, H Yanagisawa - Clinical Science, 2020 - portlandpress.com
Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …
Sex differences in cerebral aneurysms and subarachnoid hemorrhage
AM Fuentes, L Stone McGuire, S Amin-Hanjani - Stroke, 2022 - Am Heart Assoc
Sex differences in cerebral aneurysm occurrence and characteristics have been well
described. Although sex differences in outcomes following ischemic stroke have been …
described. Although sex differences in outcomes following ischemic stroke have been …
[HTML][HTML] Intracranial aneurysms: pathology, genetics, and molecular mechanisms
Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …
Vascular smooth muscle cells in intracranial aneurysms
Z Wang, J Ma, H Yue, Z Zhang, F Fang, G Wang… - Microvascular …, 2023 - Elsevier
Intracranial aneurysm (IA) is a severe cerebrovascular disease characterized by abnormal
bulging of cerebral vessels that may rupture and cause a stroke. The expansion of the …
bulging of cerebral vessels that may rupture and cause a stroke. The expansion of the …
[HTML][HTML] The relationship of morphological-hemodynamic characteristics, inflammation, and remodeling of aneurysm wall in unruptured intracranial aneurysms
Q Liu, Y Zhang, J Yang, Y Yang, M Li, S Chen… - Translational Stroke …, 2022 - Springer
Aneurysm wall remodeling (AWR) is an important pathological characteristic in aneurysm
wall, which was characterized by abnormal histological structure and inflammation …
wall, which was characterized by abnormal histological structure and inflammation …
[HTML][HTML] Why are women predisposed to intracranial aneurysm?
M Fréneau, C Baron-Menguy, AC Vion… - Frontiers in …, 2022 - frontiersin.org
Intracranial aneurysm (IA) is a frequent and generally asymptomatic cerebrovascular
abnormality characterized as a localized dilation and wall thinning of intracranial arteries …
abnormality characterized as a localized dilation and wall thinning of intracranial arteries …
[HTML][HTML] Substrate stiffness influences structural and functional remodeling in induced pluripotent stem cell-derived cardiomyocytes
A Körner, M Mosqueira, M Hecker… - Frontiers in Physiology, 2021 - frontiersin.org
Novel treatment strategies for cardiac tissue regeneration are heading for the use of
engineered cardiac tissue made from induced pluripotent stem cell-derived cardiomyocytes …
engineered cardiac tissue made from induced pluripotent stem cell-derived cardiomyocytes …
Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review
Aneurysms are malformations within the arterial vasculature brought on by the structural
breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health …
breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health …
[HTML][HTML] Bayesian network analysis reveals the interplay of intracranial aneurysm rupture risk factors
Clinical decision making regarding the treatment of unruptured intracranial aneurysms (IA)
benefits from a better understanding of the interplay of IA rupture risk factors. Probabilistic …
benefits from a better understanding of the interplay of IA rupture risk factors. Probabilistic …