Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms

J Frösen, J Cebral, AM Robertson, T Aoki - Neurosurgical focus, 2019 - thejns.org
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

The molecular mechanism of mechanotransduction in vascular homeostasis and disease

Y Yamashiro, H Yanagisawa - Clinical Science, 2020 - portlandpress.com
Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …

Sex differences in cerebral aneurysms and subarachnoid hemorrhage

AM Fuentes, L Stone McGuire, S Amin-Hanjani - Stroke, 2022 - Am Heart Assoc
Sex differences in cerebral aneurysm occurrence and characteristics have been well
described. Although sex differences in outcomes following ischemic stroke have been …

[HTML][HTML] Intracranial aneurysms: pathology, genetics, and molecular mechanisms

Z Xu, YN Rui, JP Hagan, DH Kim - Neuromolecular medicine, 2019 - Springer
Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …

Vascular smooth muscle cells in intracranial aneurysms

Z Wang, J Ma, H Yue, Z Zhang, F Fang, G Wang… - Microvascular …, 2023 - Elsevier
Intracranial aneurysm (IA) is a severe cerebrovascular disease characterized by abnormal
bulging of cerebral vessels that may rupture and cause a stroke. The expansion of the …

[HTML][HTML] The relationship of morphological-hemodynamic characteristics, inflammation, and remodeling of aneurysm wall in unruptured intracranial aneurysms

Q Liu, Y Zhang, J Yang, Y Yang, M Li, S Chen… - Translational Stroke …, 2022 - Springer
Aneurysm wall remodeling (AWR) is an important pathological characteristic in aneurysm
wall, which was characterized by abnormal histological structure and inflammation …

[HTML][HTML] Why are women predisposed to intracranial aneurysm?

M Fréneau, C Baron-Menguy, AC Vion… - Frontiers in …, 2022 - frontiersin.org
Intracranial aneurysm (IA) is a frequent and generally asymptomatic cerebrovascular
abnormality characterized as a localized dilation and wall thinning of intracranial arteries …

[HTML][HTML] Substrate stiffness influences structural and functional remodeling in induced pluripotent stem cell-derived cardiomyocytes

A Körner, M Mosqueira, M Hecker… - Frontiers in Physiology, 2021 - frontiersin.org
Novel treatment strategies for cardiac tissue regeneration are heading for the use of
engineered cardiac tissue made from induced pluripotent stem cell-derived cardiomyocytes …

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

K Sunderland, J Jiang, F Zhao - Journal of cellular physiology, 2022 - Wiley Online Library
Aneurysms are malformations within the arterial vasculature brought on by the structural
breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health …

[HTML][HTML] Bayesian network analysis reveals the interplay of intracranial aneurysm rupture risk factors

M Delucchi, GR Spinner, M Scutari, P Bijlenga… - Computers in Biology …, 2022 - Elsevier
Clinical decision making regarding the treatment of unruptured intracranial aneurysms (IA)
benefits from a better understanding of the interplay of IA rupture risk factors. Probabilistic …