Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models

DB Brückner, E Hannezo - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The importance of physical forces in the morphogenesis, homeostatic function, and
pathological dysfunction of multicellular tissues is being increasingly characterized, both …

Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces

S Stöberl, J Flommersfeld, MM Kreft, M Benoit… - Science …, 2024 - science.org
Eukaryotic cells show an astounding ability to remodel their shape and cytoskeleton and to
migrate through pores and constrictions smaller than their nuclear diameter. However, the …

[PDF][PDF] Integrating frontiers: a holistic, quantum and evolutionary approach to conquering cancer through systems biology and multidisciplinary synergy

MC Casotti, DD Meira, ASS Zetum… - Frontiers in …, 2024 - researchgate.net
Cancer occurs when cells stop working for the collective and become selfish. These
changes transform the cells, giving them competitive advantages. Cancer manifestations are …

Inferring the Langevin Equation with Uncertainty via Bayesian Neural Networks

Y Bae, S Ha, H Jeong - arXiv preprint arXiv:2402.01338, 2024 - arxiv.org
Pervasive across diverse domains, stochastic systems exhibit fluctuations in processes
ranging from molecular dynamics to climate phenomena. The Langevin equation has served …

Learning dynamical models from stochastic trajectories

P Ronceray - arXiv preprint arXiv:2406.02363, 2024 - arxiv.org
The dynamics of biological systems, from proteins to cells to organisms, is complex and
stochastic. To decipher their physical laws, we need to bridge between experimental …

[HTML][HTML] Learning Dynamics from Multicellular Graphs with Deep Neural Networks

H Yang, F Meyer, S Huang, L Yang, C Lungu… - ArXiv, 2024 - ncbi.nlm.nih.gov
The inference of multicellular self-assembly is the central quest of understanding
morphogenesis, including embryos, organoids, tumors, and many others. However, it has …

A review of active matter reviews

M Vrugt, R Wittkowski - arXiv preprint arXiv:2405.15751, 2024 - arxiv.org
In the past years, the amount of research on active matter has grown extremely rapidly, a fact
that is reflected in particular by the existence of more than 600 review articles on this topic …

Nonlinear dynamics of confined cell migration--modeling and inference

P Zadeh, BA Camley - arXiv preprint arXiv:2404.07390, 2024 - arxiv.org
The motility of eukaryotic cells is strongly influenced by their environment, with confined cells
often developing qualitatively different motility patterns from those migrating on simple two …

The actin cortex acts as a mechanical memory of morphology in confined migrating cells

Y Kalukula, M Luciano, G Charras, D Brueckner… - bioRxiv, 2024 - biorxiv.org
Cell migration in narrow microenvironments is a hallmark of numerous physiological
processes, involving successive cycles of confinement and release that drive significant …

[PDF][PDF] The role of the physical microenvironment in cell migration and cytoskeletal force generation

J Flommersfeld - 2024 - edoc.ub.uni-muenchen.de
Cellular force generation and motility are key to embryonic development, the immune
system, wound healing, and cancer. In all these examples, cells migrate and generate forces …