Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

The link between cancer metabolism and immunosuppression, inflammation and immune
escape has generated major interest in investigating the effects of low pH on tumor …

Small-cell lung cancer (SCLC) is an aggressive lung cancer subtype and its first-line
treatment has remained unchanged for decades. In recent years, immunotherapy has …

While cancer is commonly described as “a disease of the genes,” it is also associated with
massive metabolic reprogramming that is now accepted as a disease “Hallmark.” This …

The conversion of cells with an epithelial phenotype into cells with a mesenchymal
phenotype, referred to as epithelial–mesenchymal transition, is a critical process for …

Exosomes have diameter within the range of 30-100nm and spherical to cup-shaped
nanoparticles with specific surface molecular characteristics, such as CD9 and CD63. These …

Background Acidity is a hallmark of malignant tumor, representing a very efficient
mechanism of chemoresistance. Proton pump inhibitors (PPI) at high dosage have been …

Although cancer is characterized by an intratumoral genetic heterogeneity, a totally
deranged pH control is a common feature of most cancer histotypes. Major determinants of …

The initiation and progression of malignant tumors are supported by their microenvironment:
cancer cells per se cannot explain growth and formation of the primary or metastasis, and a …

Much effort is currently devoted to developing patient-specific cancer therapy based on
molecular characterization of tumors. In particular, this approach seeks to identify driver …