Unraveling the dynamics of dopamine release and its actions on target cells
T Sippy, NX Tritsch - Trends in neurosciences, 2023 - cell.com
The neuromodulator dopamine (DA) is essential for regulating learning, motivation, and
movement. Despite its importance, however, the mechanisms by which DA influences the …
movement. Despite its importance, however, the mechanisms by which DA influences the …
[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
[HTML][HTML] Monoaminergic neuromodulation of sensory processing
SN Jacob, H Nienborg - Frontiers in neural circuits, 2018 - frontiersin.org
All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …
processing and resulting behavioral changes are most commonly reported for higher order …
[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease
The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …
processing motor and non-motor information through the creation of complex connections …
[HTML][HTML] Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
[HTML][HTML] Aberrant striatal activity in parkinsonism and levodopa-induced dyskinesia
Action selection relies on the coordinated activity of striatal direct and indirect pathway
medium spiny neurons (dMSNs and iMSNs, respectively). Loss of dopamine in Parkinson's …
medium spiny neurons (dMSNs and iMSNs, respectively). Loss of dopamine in Parkinson's …
[HTML][HTML] The functional organization of cortical and thalamic inputs onto five types of striatal neurons is determined by source and target cell identities
Y Johansson, G Silberberg - Cell reports, 2020 - cell.com
To understand striatal function, it is essential to know the functional organization of the
numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we …
numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we …
Toward multisensory customer experiences: a cross-disciplinary bibliometric review and future research directions
An in-depth understanding of multisensory customer experiences could inform and
transform service experiences across the touchpoints of customer journeys. Sensory …
transform service experiences across the touchpoints of customer journeys. Sensory …
[HTML][HTML] Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
[HTML][HTML] Differential synaptic input to external globus pallidus neuronal subpopulations in vivo
M Ketzef, G Silberberg - Neuron, 2021 - cell.com
The rodent external globus pallidus (GPe) contains two main neuronal subpopulations,
prototypic and arkypallidal cells, which differ in their cellular properties. Their functional …
prototypic and arkypallidal cells, which differ in their cellular properties. Their functional …