Unraveling the dynamics of dopamine release and its actions on target cells

T Sippy, NX Tritsch - Trends in neurosciences, 2023 - cell.com
The neuromodulator dopamine (DA) is essential for regulating learning, motivation, and
movement. Despite its importance, however, the mechanisms by which DA influences the …

[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease

W Shen, S Zhai, DJ Surmeier - Neurobiology of disease, 2022 - Elsevier
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …

[HTML][HTML] Monoaminergic neuromodulation of sensory processing

SN Jacob, H Nienborg - Frontiers in neural circuits, 2018 - frontiersin.org
All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …

[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease

J Dong, S Hawes, J Wu, W Le, H Cai - Frontiers in neural circuits, 2021 - frontiersin.org
The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …

[HTML][HTML] Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner

MC Dorst, A Tokarska, M Zhou, K Lee… - Nature …, 2020 - nature.com
Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are
essential for basal ganglia function. Synchronized pauses in the activity of striatal …

[HTML][HTML] Aberrant striatal activity in parkinsonism and levodopa-induced dyskinesia

MB Ryan, C Bair-Marshall, AB Nelson - Cell reports, 2018 - cell.com
Action selection relies on the coordinated activity of striatal direct and indirect pathway
medium spiny neurons (dMSNs and iMSNs, respectively). Loss of dopamine in Parkinson's …

[HTML][HTML] The functional organization of cortical and thalamic inputs onto five types of striatal neurons is determined by source and target cell identities

Y Johansson, G Silberberg - Cell reports, 2020 - cell.com
To understand striatal function, it is essential to know the functional organization of the
numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we …

Toward multisensory customer experiences: a cross-disciplinary bibliometric review and future research directions

S Stead, R Wetzels, M Wetzels… - Journal of Service …, 2022 - journals.sagepub.com
An in-depth understanding of multisensory customer experiences could inform and
transform service experiences across the touchpoints of customer journeys. Sensory …

[HTML][HTML] Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease

S Zhai, Q Cui, DNV Simmons, DJ Surmeier - Current opinion in …, 2023 - Elsevier
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …

[HTML][HTML] Differential synaptic input to external globus pallidus neuronal subpopulations in vivo

M Ketzef, G Silberberg - Neuron, 2021 - cell.com
The rodent external globus pallidus (GPe) contains two main neuronal subpopulations,
prototypic and arkypallidal cells, which differ in their cellular properties. Their functional …