Dopamine in Parkinson's disease

S Latif, M Jahangeer, DM Razia, M Ashiq, A Ghaffar… - Clinica chimica acta, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

The microbiota–gut–brain axis and Alzheimer's disease: neuroinflammation is to blame?

A Megur, D Baltriukienė, V Bukelskienė, A Burokas - Nutrients, 2020 - mdpi.com
For years, it has been reported that Alzheimer's disease (AD) is the most common cause of
dementia. Various external and internal factors may contribute to the early onset of AD. This …

Role of reactive oxygen species in aging and age-related diseases: A review

MI Anik, N Mahmud, AA Masud, MI Khan… - ACS Applied Bio …, 2022 - ACS Publications
Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Melatonin: clinical perspectives in neurodegeneration

DP Cardinali - Frontiers in endocrinology, 2019 - frontiersin.org
Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

[HTML][HTML] Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery

S Cetin, D Knez, S Gobec, J Kos, A Pišlar - Biomedicine & …, 2022 - Elsevier
Neurodegenerative diseases are severely debilitating conditions characterized primarily by
progressive neuronal loss and impairment of the nervous system. Alzheimer's and …

Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments

TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …

Profiling of serum exosome MiRNA reveals the potential of a MiRNA panel as diagnostic biomarker for Alzheimer's disease

Z Dong, H Gu, Q Guo, S Liang, J Xue, F Yao, X Liu… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease in the older
adults. Although much effort has been made in the analyses of diagnostic biomarkers, such …

Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases

M Mistretta, A Farini, Y Torrente, C Villa - Brain, 2023 - academic.oup.com
Neurodegenerative diseases are a major global health burden particularly with the
increasing ageing population. Hereditary predisposition and environmental risk factors …

A mechanistic survey of Alzheimer's disease

Y Tang, D Zhang, X Gong, J Zheng - Biophysical chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …