Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how …

SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been
proposed as a mechanism to organize chromatin in interphase and metaphase. However …

Background NCAPD3 is one of the three non-SMC subunits of condensin II complex, which
plays an important role in the chromosome condensation and segregation during mitosis …

During cell division, chromosomes are compacted in length by more than a 100-fold. A wide
range of experiments demonstrated that in their compacted state, mammalian chromosomes …