Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

EGFR Mutations in Head and Neck Squamous Cell Carcinoma

S Nair, JA Bonner, M Bredel - International Journal of Molecular Sciences, 2022 - mdpi.com
EGFR is a prototypical receptor tyrosine kinase that is overexpressed in multiple cancers
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …

Malaria biomimetic for tumor targeted drug delivery

J Pihl, TM Clausen, J Zhou, N Krishnan… - acs Nano, 2023 - ACS Publications
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …

The role of Hedgehog signaling pathway in head and neck squamous cell carcinoma

P Cierpikowski, A Leszczyszyn, J Bar - Cells, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Unraveling molecular mechanisms of head and neck cancer

P Parashar, H Hungyo, A Jain, S Ahmad… - Critical reviews in …, 2022 - Elsevier
Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …

Isolation and characterization of head and neck cancer-derived peritumoral and cancer-associated fibroblasts

J Zhou, S Schwenk-Zieger, G Kranz, C Walz… - Frontiers in …, 2022 - frontiersin.org
Introduction Head and neck squamous cell carcinomas (HNSCC) are characterized by
strong cellular and molecular heterogeneity and treatment resistance entailing poor survival …

[HTML][HTML] Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck

RL Ferris, K Harrington, JD Schoenfeld… - Cancer Treatment …, 2023 - Elsevier
Standard of care for patients with locally advanced squamous cell carcinoma of the head
and neck (LA SCCHN) is surgery followed by chemoradiotherapy (CRT) or definitive CRT …

Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment

JL Farlow, JC Brenner, YL Lei, SB Chinn - Oral oncology, 2021 - Elsevier
Immunotherapy revolutionized cancer treatment but has yet to elicit durable responses in the
majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is …

Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance

E Muraro, G Fanetti, V Lupato, V Giacomarra… - Critical Reviews in …, 2021 - Elsevier
Since its introduction, the use of cetuximab in the treatment of head and neck squamous cell
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …

Non-coding RNA-mediated autophagy in cancer: A protumor or antitumor factor?

J Liang, L Zhang, W Cheng - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Autophagy, usually referred to as macroautophagy, is a cytoprotective behavior that helps
cells, especially cancer cells, escape crises. However, the role of autophagy in cancer …