Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine
H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
EGFR Mutations in Head and Neck Squamous Cell Carcinoma
S Nair, JA Bonner, M Bredel - International Journal of Molecular Sciences, 2022 - mdpi.com
EGFR is a prototypical receptor tyrosine kinase that is overexpressed in multiple cancers
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …
Malaria biomimetic for tumor targeted drug delivery
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …
The role of Hedgehog signaling pathway in head and neck squamous cell carcinoma
P Cierpikowski, A Leszczyszyn, J Bar - Cells, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …
Unraveling molecular mechanisms of head and neck cancer
P Parashar, H Hungyo, A Jain, S Ahmad… - Critical reviews in …, 2022 - Elsevier
Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …
Isolation and characterization of head and neck cancer-derived peritumoral and cancer-associated fibroblasts
J Zhou, S Schwenk-Zieger, G Kranz, C Walz… - Frontiers in …, 2022 - frontiersin.org
Introduction Head and neck squamous cell carcinomas (HNSCC) are characterized by
strong cellular and molecular heterogeneity and treatment resistance entailing poor survival …
strong cellular and molecular heterogeneity and treatment resistance entailing poor survival …
[HTML][HTML] Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck
RL Ferris, K Harrington, JD Schoenfeld… - Cancer Treatment …, 2023 - Elsevier
Standard of care for patients with locally advanced squamous cell carcinoma of the head
and neck (LA SCCHN) is surgery followed by chemoradiotherapy (CRT) or definitive CRT …
and neck (LA SCCHN) is surgery followed by chemoradiotherapy (CRT) or definitive CRT …
Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment
Immunotherapy revolutionized cancer treatment but has yet to elicit durable responses in the
majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is …
majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is …
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance
E Muraro, G Fanetti, V Lupato, V Giacomarra… - Critical Reviews in …, 2021 - Elsevier
Since its introduction, the use of cetuximab in the treatment of head and neck squamous cell
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …
carcinoma (HNSCC) has experienced an evolution. Currently, cetuximab associated with …
Non-coding RNA-mediated autophagy in cancer: A protumor or antitumor factor?
J Liang, L Zhang, W Cheng - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Autophagy, usually referred to as macroautophagy, is a cytoprotective behavior that helps
cells, especially cancer cells, escape crises. However, the role of autophagy in cancer …
cells, especially cancer cells, escape crises. However, the role of autophagy in cancer …