COVID-19 and the chemical senses: supporting players take center stage

KW Cooper, DH Brann, MC Farruggia, S Bhutani… - Neuron, 2020 - cell.com
The main neurological manifestation of COVID-19 is loss of smell or taste. The high
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

S SantaCruz-Calvo, L Bharath, G Pugh… - Nature Reviews …, 2022 - nature.com
Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Bitter, sweet, salty, sour and umami taste perception decreases with age: Sex-specific analysis, modulation by genetic variants and taste-preference associations in 18 …

R Barragán, O Coltell, O Portolés, EM Asensio, JV Sorlí… - Nutrients, 2018 - mdpi.com
There is growing interest in relating taste perception to diet and healthy aging. However,
there is still limited information on the influence of age, sex and genetics on taste acuity as …

The pathogenesis of obesity

SM Oussaada, KA Van Galen, MI Cooiman… - Metabolism, 2019 - Elsevier
Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

SARS-CoV-2 Receptor ACE2 Is Enriched in a Subpopulation of Mouse Tongue Epithelial Cells in Nongustatory Papillae but Not in Taste Buds or Embryonic Oral …

Z Wang, J Zhou, B Marshall, R Rekaya… - ACS pharmacology & …, 2020 - ACS Publications
As a result of the COVID-19 pandemic, evidence revealed that SARS-CoV-2 infection
caused taste loss at a rate higher than that of influenza. ACE2, the entry receptor of SARS …

High dietary sugar reshapes sweet taste to promote feeding behavior in Drosophila melanogaster

CE May, A Vaziri, YQ Lin, O Grushko, M Khabiri… - Cell reports, 2019 - cell.com
Recent studies find that sugar tastes less intense to humans with obesity, but whether this
sensory change is a cause or a consequence of obesity is unclear. To tackle this question …

The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception

I Schamarek, L Anders, RM Chakaroun, P Kovacs… - Nutrition journal, 2023 - Springer
Obesity and its metabolic sequelae still comprise a challenge when it comes to
understanding mechanisms, which drive these pandemic diseases. The human microbiome …

Metabolic and feeding adjustments during pregnancy

R Haddad-Tóvolli, M Claret - Nature Reviews Endocrinology, 2023 - nature.com
Eating behaviours are determined by the integration of interoceptive and environmental
inputs. During pregnancy, numerous physiological adaptations take place in the maternal …

Obesity-induced taste dysfunction, and its implications for dietary intake

F Harnischfeger, R Dando - International Journal of Obesity, 2021 - nature.com
The incidence of obesity has dramatically increased in recent years, and poses a public
health challenge for which an effective and scalable intervention strategy is yet to be found …

Taste loss with obesity in mice and men

A Kaufman, J Kim, C Noel, R Dando - International journal of obesity, 2020 - nature.com
Background Our sense of taste is critical in defining our food choices and habits. Located
primarily in our tongue, taste buds are small assemblies of constantly renewing sensory …