Coronavirus disease 2019 (COVID-19) in children-what we know so far and what we do not

S Balasubramanian, NM Rao, A Goenka, M Roderick… - Indian pediatrics, 2020 - Springer
Abstract Pediatric coronavirus disease-19 (COVID-19) infection is relatively mild when
compared to adults, and children are reported to have a better prognosis. Mortality in …

[HTML][HTML] Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …

Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance

KM Sheu, A Hoffmann - Annual review of immunology, 2022 - annualreviews.org
Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

[HTML][HTML] COVID-19 pandemic and vaccines update on challenges and resolutions

WH Khan, Z Hashmi, A Goel, R Ahmad… - Frontiers in cellular …, 2021 - frontiersin.org
The coronavirus disease (COVID-19) is caused by a positive-stranded RNA virus called
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), belonging to the …

[HTML][HTML] Could BCG vaccination induce protective trained immunity for SARS-CoV-2?

C Covián, A Retamal-Díaz, SM Bueno… - Frontiers in …, 2020 - frontiersin.org
Trained immunity is a type of non-specific memory-like immune response induced by some
pathogens and vaccines, such as BCG, which can confer antigen-independent protection …

Optimize prime/boost vaccine strategies: trained immunity as a new player in the game

JL Palgen, Y Feraoun, G Dzangué-Tchoupou… - Frontiers in …, 2021 - frontiersin.org
Most vaccines require multiple doses to induce long-lasting protective immunity in a high
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

J Yan, TB Nielsen, P Lu, Y Talyansky… - Science Translational …, 2023 - science.org
Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant,
nosocomial pathogens that cause health care–associated infections. We developed a …

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

C Counoupas, MD Johansen, AO Stella, DH Nguyen… - npj Vaccines, 2021 - nature.com
Global control of COVID-19 requires broadly accessible vaccines that are effective against
SARS-CoV-2 variants. In this report, we exploit the immunostimulatory properties of bacille …

Is BCG vaccination affecting the spread and severity of COVID‐19?

C Ozdemir, UC Kucuksezer, ZU Tamay - Allergy, 2020 - search.ebscohost.com
Is BCG vaccination affecting the spread and severity of COVID-19? C, Effects of BCG
vaccination on COVID-19 pandemics in European countries [BCG-vaccinated countries (n …

Tuberculosis and COVID‐19: lessons from the past viral outbreaks and possible future outcomes

R Crisan-Dabija, C Grigorescu… - Canadian respiratory …, 2020 - Wiley Online Library
Background. The threat of contagious infectious diseases is constantly evolving as
demographic explosion, travel globalization, and changes in human lifestyle increase the …