Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

The homeostasis of the central nervous system (CNS) is ensured by the endothelial,
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …

Myelin sheaths provide critical functional and trophic support for axons in white matter tracts
of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic …

Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …