Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Background Inflammaging represents an accepted concept where the immune system shifts
to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS …

Acute brain injuries evoke various response cascades directing the formation of the glial
scar. Here, we report that acute lesions associated with hemorrhagic injuries trigger a re …

Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and
nonhuman primates - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

The disruption of the blood–brain barrier (BBB) plays a critical role in the pathology of
ischemic stroke. p75 neurotrophin receptor (p75NTR) contributes to the disruption of the …

The cerebrovasculature is essential to brain health and is tasked with ensuring adequate
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …

Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain;
however, their function is rather heterogeneous in respect to their origin, location …

Building a functional nervous system requires the coordinated actions of many glial cells. In
the vertebrate central nervous system (CNS), oligodendrocytes myelinate neuronal axons to …

Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Acute
neuroinflammation is a prominent reaction after TBI and is mostly initiated by brain-resident …