Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives

K Mortezaee, M Najafi - Critical reviews in oncology/hematology, 2021 - Elsevier
Radiotherapy is a common modality for more than half of cancer patients. Classically,
radiation is known as a strategy to kill cancer cells via direct interaction with DNA or …

The role of the estrogen pathway in the tumor microenvironment

NJ Rothenberger, A Somasundaram… - International journal of …, 2018 - mdpi.com
Estrogen receptors are broadly expressed in many cell types involved in the innate and
adaptive immune responses, and differentially regulate the production of cytokines. While …

Mouse tumor models for advanced cancer immunotherapy

DS Chulpanova, KV Kitaeva, CS Rutland… - International journal of …, 2020 - mdpi.com
Recent advances in the development of new methods of cancer immunotherapy require the
production of complex cancer animal models that reliably reflect the complexity of the tumor …

Sex and gender differences in lung cancer and chronic obstructive lung disease

JM Siegfried - Endocrinology, 2022 - academic.oup.com
Two highly prevalent pulmonary diseases, lung cancer and chronic obstructive lung disease
(COPD), show both sex and gender differences in their presentations and outcomes. Sex …

[HTML][HTML] Influence of estrogen on the NSCLC microenvironment: a comprehensive picture and clinical implications

T Smida, TC Bruno, LP Stabile - Frontiers in Oncology, 2020 - frontiersin.org
Lung cancer mortality represents the leading cause of cancer related deaths in the United
States and worldwide. Almost half of these deaths occur in female patients, making lung …

Targeting inflammation in non-small cell lung cancer through drug repurposing

T Rajasegaran, CW How, A Saud, A Ali, JCW Lim - Pharmaceuticals, 2023 - mdpi.com
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …

Targets for improving tumor response to radiotherapy

K Mortezaee, W Parwaie, E Motevaseli… - International …, 2019 - Elsevier
Radiotherapy is one of the most common treatment modalities for controlling a wide range of
tumors. However, it has been shown that radiotherapy alone is unable to completely …

Estrogens, cancer and immunity

I Orzołek, J Sobieraj, J Domagała-Kulawik - Cancers, 2022 - mdpi.com
Simple Summary In this review, we present current knowledge of sex hormones in the
process of development of malignant diseases. The impact of sex hormones on immune …

Chronic inflammation and cancer; the two sides of a coin

Q Fernandes, VP Inchakalody, T Bedhiafi, S Mestiri… - Life Sciences, 2023 - Elsevier
The correlation between chronic inflammation and cancer was initially identified in the 19th
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …