TGF‐β superfamily co‐receptors in cancer

JB Pawlak, GC Blobe - Developmental Dynamics, 2022 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …

[HTML][HTML] Aptamer-based CRISPR/Cas12a assay for the ultrasensitive detection of extracellular vesicle proteins

H Li, S Xing, J Xu, Y He, Y Lai, Y Wang, G Zhang… - Talanta, 2021 - Elsevier
Tumor-derived extracellular vesicles (TEVs) have emerged as promising sources of
diagnostic and prognostic biomarkers for nasopharyngeal carcinoma (NPC). However, the …

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution

F Ye, G Zhang, WE, H Chen, C Yu, L Yang… - Nature …, 2022 - nature.com
Abstract The Mexican axolotl (Ambystoma mexicanum) is a well-established tetrapod model
for regeneration and developmental studies. Remarkably, neotenic axolotls may undergo …

The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β

M Tanabe, K Hosokawa, MAT Nguyen, N Nakagawa… - Leukemia, 2022 - nature.com
Although a glycosylphosphatidylinositol-anchored protein (GPI-AP) CD109 serves as a TGF-
β co-receptor and inhibits TGF-β signaling in keratinocytes, the role of CD109 on …

Applications of CRISPR‐Cas9 in gynecological cancer research

W Zhang, Y Liu, X Zhou, R Zhao, H Wang - Clinical Genetics, 2020 - Wiley Online Library
Gynecological cancers pose a significant threat to women's health worldwide, with cervical
cancer, ovarian cancer, and endometrial cancer having high incidences. Current …

CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma

XT Mo, THY Leung, HWM Tang, MKY Siu… - British Journal of …, 2020 - nature.com
Background CD109 was involved in the tumorigenesis and progression of various cancers
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …

Upregulation of CD109 promotes the epithelial-to-mesenchymal transition and stemness properties of lung adenocarcinomas via activation of the hippo-YAP signaling

KY Lee, TC Kuo, CM Chou, WJ Hsu, WC Lee, JZ Dai… - Cells, 2020 - mdpi.com
Metastasis is the leading cause of death in lung adenocarcinomas. Identifying potential
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …

A New Assessment of Thioester-Containing Proteins Diversity of the Freshwater Snail Biomphalaria glabrata

D Duval, R Pichon, D Lassalle, M Laffitte, B Gourbal… - Genes, 2020 - mdpi.com
Thioester-containing proteins (TEPs) superfamily is known to play important innate immune
functions in a wide range of animal phyla. TEPs are involved in recognition, and in the direct …

CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells

S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …

Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway

YH Han, YQ Zhang, MH Jin, YH Jin, MY Qiu… - Biochemical and …, 2020 - Elsevier
Keratinocyte hyperproliferation is an essential link in skin cancer pathogenesis.
Peroxiredoxin I (Prx I) is known to regulate cancer cell proliferation, differentiation, and …