Balanced rearrangements involving the KMT2A gene (KMT2A r) are recurrent genetic
abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the …

Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

Despite major treatment improvements over the past decades, pediatric acute myeloid
leukemia (AML) is still a life-threatening malignancy with relapse rates up to 30% and …

Infants< 1 year of age have a high prevalence of prognostically unfavorable leukemias and
a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute …

A disease risk index (DRI) that was developed for adults with hematologic malignancy who
were undergoing hematopoietic cell transplantation is also being used to stratify children …

The last decades have seen parallel improvements in chemotherapy‐based and
haematopoietic stem cell transplantation (HSCT) regimens for acute myeloid leukaemia …

Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific
patterns of gene expression and enhancer architecture, implying unique core transcriptional …

Chromosomal translocations involving the NUP98 locus are among the most prevalent
rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is …

Despite constant progress in prognostic risk stratification, children with acute myeloid
leukemia (AML) still relapse. Treatment failure and subsequent relapse have been attributed …

Acute monoblastic/monocytic leukemia (AMoL), previously defined as M5 according to FAB
classification, is one of the most common subtypes of Acute Myeloid Leukemia (AML) in …