The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4
(H3K4) methylation, a conserved trait of euchromatin associated with transcriptional …

The spectrum of chromosomal abnormality associated with leukemogenesis of acute
myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid …

Background The role of allogeneic stem cell transplantation in post-remission management
of children with high-risk acute myeloid leukemia remains controversial. In the multi-center …

New methods like panel-based RNA fusion sequencing (RNA-FS) promise improved
diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial …

Background The prognostic significance of extramedullary leukemia (EML) in childhood
acute myeloid leukemia is not clarified. Procedure This population‐based study included …

Children aged 0–2 years (ie, infants) with acute myeloid leukemia (AML) are a peculiar
subgroup of patients in the childhood AML scenario. They present with distinctive biological …

Identification of pediatric patients with acute myeloid leukemia (AML) candidates to receive
allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission …

Comprehensive clinical studies of patients with acute megakaryoblastic leukemia (AMKL)
are lacking. We performed an international retrospective study on 490 patients (age≤ 18 …

Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between
Western European countries exists. The aim of the current study is to assess the progress …

A number of chromosomal aberrations have been reported in hematological malignancies.
Recent studies have demonstrated that several chromosomal abnormalities and molecular …