Hamster models of COVID-19 pneumonia reviewed: How human can they be?
AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …
soon fueled quests for a suitable model that would facilitate the development and testing of …
[HTML][HTML] Ethical considerations regarding animal experimentation
Animal experimentation is widely used around the world for the identification of the root
causes of various diseases in humans and animals and for exploring treatment options …
causes of various diseases in humans and animals and for exploring treatment options …
[HTML][HTML] Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice
F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …
[HTML][HTML] The status and prospects of Epstein–Barr virus prophylactic vaccine development
Epstein–Barr virus (EBV) is a human herpesvirus that is common among the global
population, causing an enormous disease burden. EBV can directly cause infectious …
population, causing an enormous disease burden. EBV can directly cause infectious …
A biosafety level 2 mouse model for studying betacoronavirus-induced acute lung damage and systemic manifestations
ACSP Andrade, GH Campolina-Silva… - Journal of …, 2021 - Am Soc Microbiol
The emergence of life-threatening zoonotic diseases caused by betacoronaviruses,
including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the …
including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the …
[HTML][HTML] ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues
With the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more
than 65 million cases have been reported worldwide. This virus has shown high infectivity …
than 65 million cases have been reported worldwide. This virus has shown high infectivity …
[HTML][HTML] Cell and animal models for SARS-CoV-2 research
During the last two years following the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a …
(SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a …
Prototype mouse models for researching SEND-based mRNA delivery and gene therapy
CB Gurumurthy, RM Quadros, M Ohtsuka - Nature protocols, 2022 - nature.com
One of the major challenges of gene therapy—an approach to treat diseases caused by
faulty genes—is a lack of technologies that deliver healthy gene copies to target tissues and …
faulty genes—is a lack of technologies that deliver healthy gene copies to target tissues and …
[HTML][HTML] Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention
V Bhardwaj, M Dela Cruz, D Subramanyam, R Kumar… - Plos one, 2022 - journals.plos.org
Background The Covid-19 pandemic has emerged as the leading public health challenge of
our time (20th century). While vaccinations have finally blunted the death rate, concern has …
our time (20th century). While vaccinations have finally blunted the death rate, concern has …
[HTML][HTML] Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic
K Ekstrand, AJ Flanagan, IE Lin, B Vejseli, A Cole… - Animals, 2021 - mdpi.com
Simple Summary The accelerated pace of research into Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) necessitates periodic summaries of current …
Syndrome Coronavirus 2 (SARS-CoV-2) necessitates periodic summaries of current …