Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

[HTML][HTML] Ethical considerations regarding animal experimentation

AK Kiani, D Pheby, G Henehan, R Brown… - Journal of preventive …, 2022 - ncbi.nlm.nih.gov
Animal experimentation is widely used around the world for the identification of the root
causes of various diseases in humans and animals and for exploring treatment options …

[HTML][HTML] Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice

F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …

[HTML][HTML] The status and prospects of Epstein–Barr virus prophylactic vaccine development

C Sun, X Chen, Y Kang, M Zeng - Frontiers in Immunology, 2021 - frontiersin.org
Epstein–Barr virus (EBV) is a human herpesvirus that is common among the global
population, causing an enormous disease burden. EBV can directly cause infectious …

A biosafety level 2 mouse model for studying betacoronavirus-induced acute lung damage and systemic manifestations

ACSP Andrade, GH Campolina-Silva… - Journal of …, 2021 - Am Soc Microbiol
The emergence of life-threatening zoonotic diseases caused by betacoronaviruses,
including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the …

[HTML][HTML] ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

S Badawi, BR Ali - Human genomics, 2021 - Springer
With the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more
than 65 million cases have been reported worldwide. This virus has shown high infectivity …

[HTML][HTML] Cell and animal models for SARS-CoV-2 research

E Bestion, P Halfon, S Mezouar, JL Mège - Viruses, 2022 - mdpi.com
During the last two years following the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a …

Prototype mouse models for researching SEND-based mRNA delivery and gene therapy

CB Gurumurthy, RM Quadros, M Ohtsuka - Nature protocols, 2022 - nature.com
One of the major challenges of gene therapy—an approach to treat diseases caused by
faulty genes—is a lack of technologies that deliver healthy gene copies to target tissues and …

[HTML][HTML] Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention

V Bhardwaj, M Dela Cruz, D Subramanyam, R Kumar… - Plos one, 2022 - journals.plos.org
Background The Covid-19 pandemic has emerged as the leading public health challenge of
our time (20th century). While vaccinations have finally blunted the death rate, concern has …

[HTML][HTML] Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic

K Ekstrand, AJ Flanagan, IE Lin, B Vejseli, A Cole… - Animals, 2021 - mdpi.com
Simple Summary The accelerated pace of research into Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) necessitates periodic summaries of current …