The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation
DA Hesselink, R Bouamar, L Elens… - Clinical …, 2014 - Springer
The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …
A review of clinical pharmacogenetics Studies in African populations
F Radouani, L Zass, Y Hamdi, J Rocha… - Personalized …, 2020 - Taylor & Francis
Effective interventions and treatments for complex diseases have been implemented
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …
A low-cost, high-quality new drug discovery process using patient-derived induced pluripotent stem cells
S Giri, A Bader - Drug discovery today, 2015 - Elsevier
Highlights•Preclinical animal models are not reliable for human clinical trials.•Post-
marketing failure and black box warnings of approved market drugs are shown.•Key gates …
marketing failure and black box warnings of approved market drugs are shown.•Key gates …
CYP3A5 Gene-Guided Tacrolimus Treatment of Living-Donor Egyptian Kidney Transplanted Patients
E Mendrinou, ME Mashaly, AM Al Okily… - Frontiers in …, 2020 - frontiersin.org
Background Tacrolimus is an approved first-line immunosuppressive agent for kidney
transplantations. Part of interindividual and interethnic differences in the response of …
transplantations. Part of interindividual and interethnic differences in the response of …
[PDF][PDF] Effects of genetic polymorphism in CYP3A4 and CYP3A5 genes on tacrolimus dose among kidney transplant recipients
Introduction: This study aimed to evaluate the effects of single nucleotide POLYMORPHISM
s CYP3A 4* 1B and CYP3A 5* 3 on TACROLIMUS dose requirement among kidney …
s CYP3A 4* 1B and CYP3A 5* 3 on TACROLIMUS dose requirement among kidney …
Functional polymorphism of CYP2B6 G15631T is associated with hematologic and cytogenetic response in chronic myeloid leukemia patients treated with imatinib
Y Kassogue, M Quachouh, H Dehbi, A Quessar… - Medical Oncology, 2014 - Springer
In the spite of the impressive results achieved with imatinib in chronic myeloid leukemia
(CML) patients, differences in patient's response are observed, which may be explained by …
(CML) patients, differences in patient's response are observed, which may be explained by …
Investigation of CYP 3A5 and ABCB1 gene polymorphisms in the long-term following renal transplantation: Effects on tacrolimus exposure and kidney function
NZ Stefanović, TP Cvetković… - Experimental and …, 2015 - spandidos-publications.com
The clinical use of tacrolimus (Tac) is complicated by the large inter-individual variability in
its pharmacokinetics as well as by chronic adverse effects on renal function. The main goal …
its pharmacokinetics as well as by chronic adverse effects on renal function. The main goal …
[PDF][PDF] The frequencies distribution of CYP3A5 rs776746 and ABCB1 rs1045642 polymorphisms in the west Algerian population and relationships with …
A Ammour, M Aberkane, A Boudjema… - African Health …, 2024 - ajol.info
The Frequencies distribution of CYP3A5 rs776746 and ABCB1 rs1045642 polymorphisms in
the west Algerian population and relationsh Page 1 The Frequencies distribution of CYP3A5 …
the west Algerian population and relationsh Page 1 The Frequencies distribution of CYP3A5 …
Effect of ABCB1 3435C> T genetic polymorphism on pharmacokinetic variables of tacrolimus in adult renal transplant recipients: a systematic review and meta …
W Peng, Y Lin, H Zhang, K Meng - Clinical Therapeutics, 2020 - Elsevier
Purpose Tacrolimus is the substrate of multidrug-resistance 1 (ABCB1). However, the effect
of ABCB1 C3435T polymorphism on pharmacokinetic variables of tacrolimus is controversial …
of ABCB1 C3435T polymorphism on pharmacokinetic variables of tacrolimus is controversial …
Cytochrome and sulfotransferase gene variation in north African populations
A Fernández-Santander, A Novillo, M Gaibar… - …, 2016 - Taylor & Francis
Aim: To describe the diversity of four cytochrome and four sulfotransferase polymorphisms in
six north African samples. Scarce data have been compiled for these samples despite the …
six north African samples. Scarce data have been compiled for these samples despite the …