Simple Summary Immunotherapy has demonstrated the ability to reduce the risk of
recurrence for melanoma following surgical resection and improve survival in patients with …

Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …

Designed oligonucleotides can self-assemble into DNA nanostructures with well-defined
structures and uniform sizes, which provide unprecedented opportunities for biosensing …

DNA containing unmethylated CpG dinucleotides, or CpG motifs,(CpG DNA) has been
explored as a therapeutic agent, owing to its potent immunostimulatory activity. A previous …

The adaptive immune system has been the main focus of immunological strategies in
oncology with only more recent approaches targeting innate immunity. Endosomal toll-like …

WEIKWRHPSBSLNX-UHFFFAOYSA-N [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-
yl] methyl [5-(4-amino-2-oxopyrimidin-1-yl)-2-(phosphonooxymethyl) oxolan-3-yl] hydrogen …

DNA containing unmethylated CpG dinucleotides (CpG DNA) is a potent activator of innate
and acquired immune responses. Although the sequence‐specific immunostimulatory …

Unmethylated cytosine–phosphate–guanine (CpG) oligodeoxynucleotides (ODNs), which
were therapeutic DNA with high immunostimulatory activity, have been applied in …

BACKGROUND/AIMS: Bacterial DNA and synthetic oligonucleotides containing
unmethylated motifs have become the focus of many studies due to their ability to activate …

Innate immune responses recognizing pathogen associated molecular patterns play
important roles in adaptive immunity. As such, ligands which mimic the conserved products …