Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is
characterized by massive cytokine release and T cell loss. The exaggerated host immune …

This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

Background The Primary Immune Deficiency Treatment Consortium was formed to analyze
the results of hematopoietic-cell transplantation in children with severe combined …

Importance Newborn screening for severe combined immunodeficiency (SCID) using
assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

Summary Background Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary
immunodeficiency characterised by microthrombocytopenia, infections, eczema …

Importance Wiskott-Aldrich syndrome is a rare primary immunodeficiency associated with
severe microthrombocytopenia. Partially HLA antigen–matched allogeneic hematopoietic …

An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection
began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure …

Natural killer (NK) cells are part of the innate immune defense against infection and cancer
and are especially useful in combating certain viral pathogens. The utility of NK cells in …

Translational data on chimeric antigen receptor (CAR) T-cell trials indicate that the presence
of naïve T cells in the premanufacture product is important to clinical response and …