[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers

R Mallick, S Basak, AK Duttaroy - Progress in lipid research, 2021 - Elsevier
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

Role of oleic acid in immune system; mechanism of action; a review

C Carrillo Pérez, MM Cavia Camarero… - … , 2012, v. 27, n. 4 (julio …, 2012 - riubu.ubu.es
Introduction: Although n-3 polyunsaturated fatty acids have been widely described as
antiinflammatory fats, little is known about the role of oleic acid in immune system. Aim: The …

The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: implications for the treatment of depression, PTSD, and suicidal behaviors

J Du, M Zhu, H Bao, B Li, Y Dong, C Xiao… - Critical reviews in …, 2016 - Taylor & Francis
Numerous studies have linked severe stress to the development of major depressive
disorder (MDD) and suicidal behaviors. Furthermore, recent preclinical studies from our …

[PDF][PDF] Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent‐resistant membranes

JW Park, WJ Park, Y Kuperman, S Boura‐Halfon… - …, 2013 - Wiley Online Library
Sphingolipids are important structural components of cell membranes and act as critical
regulators of cell function by modulating intracellular signaling pathways. Specific …

n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft …

W Kim, YY Fan, R Barhoumi, R Smith… - The Journal of …, 2008 - journals.aai.org
The molecular properties of immunosuppressive n-3 polyunsaturated fatty acids (PUFA)
have not been fully elucidated. Using CD4+ T cells from wild-type control and fat-1 …

Spatial organization of transmembrane receptor signalling

I Bethani, SS Skånland, I Dikic, A Acker‐Palmer - The EMBO journal, 2010 - embopress.org
The spatial organization of transmembrane receptors is a critical step in signal transduction
and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and …

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

T Puig, H Aguilar, S Cufí, G Oliveras, C Turrado… - Breast Cancer …, 2011 - Springer
Abstract Introduction Inhibiting the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of
breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 …

Fish oil lipid emulsions and immune response: what clinicians need to know

DL Waitzberg, RS Torrinhas - Nutrition in Clinical Practice, 2009 - Wiley Online Library
Current evidence indicates that ω‐3 polyunsaturated fatty acids (PUFAs), particularly
eicosapentaenoic acid and docosahexaenoic acid found in fish oil, can prevent the …

Cholesterol is found to reside in the center of a polyunsaturated lipid membrane

TA Harroun, J Katsaras, SR Wassall - Biochemistry, 2008 - ACS Publications
Previously, we reported neutron diffraction studies on the depth of cholesterol in
phosphatidylcholine (PC) bilayers with varying amounts of acyl chain unsaturation [Harroun …

Rafts making and rafts braking: how plant flavonoids may control membrane heterogeneity

YS Tarahovsky, EN Muzafarov, YA Kim - Molecular and cellular …, 2008 - Springer
Plant flavonoids are not only known as powerful antioxidants, but also as cell metabolism
regulators. It has been postulated that they are able to control cell signal pathways by …