Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

On-line analysis of exhaled breath offers insight into a person's metabolism without the need
for sample preparation or sample collection. Due to its noninvasive nature and the possibility …

Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis
(CF). Although CF lung disease is primarily an infectious disorder, the associated …

The interaction between respiratory pathogens and their hosts is complex and incompletely
understood. This is particularly true when pathogens encounter the mucus layer covering …

Pseudomonas aeruginosa is an important opportunistic human pathogen. Using its arsenal
of virulence factors and its intrinsic ability to adapt to new environments, P. aeruginosa …

Studies of biopsies from infectious sites, explanted tissue and medical devises have
provided evidence that biofilms are the underlying cause of a variety of tissue-associated …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic
disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung …