Regulation of small gtpases by gefs, gaps, and gdis
J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
Rho GTPases as therapeutic targets in Alzheimer's disease
BJ Aguilar, Y Zhu, Q Lu - Alzheimer's research & therapy, 2017 - Springer
The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …
led to the identification of several novel pathways and potential therapeutic targets. Rho …
Desmin in muscle and associated diseases: beyond the structural function
Desmin is a muscle-specific type III intermediate filament essential for proper muscular
structure and function. In human, mutations affecting desmin expression or promoting its …
structure and function. In human, mutations affecting desmin expression or promoting its …
Characterization of thyroid cancer driven by known and novel ALK fusions
F Panebianco, AV Nikitski… - Endocrine-related …, 2019 - erc.bioscientifica.com
ALK fusions are found in various tumors, including thyroid cancer, and serve as a diagnostic
marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid …
marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid …
Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo
Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs)
such as WASP, plays an important role in many actin-mediated cellular processes. In yeast …
such as WASP, plays an important role in many actin-mediated cellular processes. In yeast …
[HTML][HTML] Regulating dynamin dynamics during endocytosis
AC Sundborger, JE Hinshaw - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Dynamin is a large GTPase that mediates plasma membrane fission during clathrin-
mediated endocytosis. Dynamin assembles into polymers on the necks of budding …
mediated endocytosis. Dynamin assembles into polymers on the necks of budding …
[HTML][HTML] Intersectin scaffold proteins and their role in cell signaling and endocytosis
E Herrero-Garcia, JP O'Bryan - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …
Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks
KA Wong, J Wilson, A Russo, L Wang, MN Okur… - PLoS …, 2012 - journals.plos.org
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular
domains, each with distinct ligand preferences. Although ITSNs were initially implicated in …
domains, each with distinct ligand preferences. Although ITSNs were initially implicated in …
Intersectin goes nuclear: secret life of an endocytic protein
Intersectin 1-short (ITSN1-s) is a 1220 amino acid ubiquitously expressed scaffold protein
presenting a multidomain structure that allows to spatiotemporally regulate the functional …
presenting a multidomain structure that allows to spatiotemporally regulate the functional …
Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity
N London, CL Lamphear, JL Hougland… - PLoS computational …, 2011 - journals.plos.org
Farnesylation is an important post-translational modification catalyzed by
farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is …
farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is …