Spatial disorientation and navigational impairments are not only some of the first memory
deficits in Alzheimer's disease, but are also very disease-specific. In rodents, the Morris …

Alzheimer's disease (AD) patients show age-related decreases in the ability to perform
activities of daily living and the decline in these activities is related to the severity of …

Background: There is an urgent need for novel therapies to treat Alzheimer's disease.
Among others, the use of cannabinoids such as delta-9-tetrahydrocannabinol (THC) and …

Evident similarities in pathological features in aging and Alzheimer's disease (AD) raise the
question of a role for natural age-related adaptive mechanisms in the prevention/elimination …

The 5xFAD mouse model shows age-related weight loss as well as cognitive and motor
deficits. Metabolic dysregulation, especially impaired insulin signaling, is also present in AD …

In the study of transgenic mouse models of neurodevelopmental and neurodegenerative
disorders, we use batteries of tests to measure deficits in behaviour and from the results of …

Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer's disease (AD) may be the
mechanism relating age-related metabolic disorders to dementia. Since Igf2 is an imprinted …

The present work examines behavioural and psychological symptoms of dementia (BPSD)-
like behaviours in the 5xFAD mouse model of Alzheimer's disease (AD)-related amyloid …

Male and female 3xTg-AD mice between 5 and 24 mo of age and their B6129F2/J wild-type
controls were tested on a series of 18 olfactory discrimination and reversal tasks in an …