Analgesics currently available for the treatment of pain following ophthalmic surgery or injury
are limited by transient effectiveness and undesirable or adverse side effects. The cornea is …

purpose. To compare sensation and sensitivity evoked from human cornea and conjunctiva
stimulated by CO 2. methods. Twenty healthy participants were recruited for the study …

Metabolic hyperactivity or limited oxygen supply can cause a decrease of tissue pH. Severe
tissue acidosis that accompanies ischemia and most forms of inflammation is painful and …

Most primary sensory neurones depend on neurotrophins for survival. Mutant mice in which
TrkA, the high‐affinity receptor for nerve growth factor (NGF), has been inactivated lack …

Our objective was to evaluate promotion of tissue and nerve regeneration by extracellular
matrix (ECM) mimics, using corneal implantation as a model system. Porcine type I collagen …

Corneal afferent nerves project to two spatially distinct sites within the spinal trigeminal
nucleus: the subnucleus interpolaris/caudalis transition and the subnucleus caudalis/upper …

Sensory nerve fibers innervating the ocular anterior surface detect external stimuli producing
innocuous and painful sensations. Protons are among the first mediators released by …

Background: Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin
analog resiniferatoxin (RTX) results in long lasting pain relief. RTX is particularly adaptable …

Aims: To determine the repeatability of ocular surface sensitivity to mechanical stimulation
using air stimuli and the effect of contact lens (CL) wear on sensitivity. Methods …

The possibility of introducing eye-wiping test as a model of acute pain was examined in rat,
and it was compared with the well-known hot plate test. One drop of NaCl 5 M was placed …