Therapeutic properties of highly selective β-blockers with or without additional vasodilator properties: focus on bisoprolol and nebivolol in patients with cardiovascular …

W AlHabeeb, S Mrabeti, AAI Abdelsalam - Cardiovascular Drugs and …, 2022 - Springer
Bisoprolol and nebivolol are highly selective β1-adrenoceptor antagonists, with clinical
indications in many countries within the management of heart failure with reduced left …

Beta-blockers in hypertension

CVS Ram - The American journal of cardiology, 2010 - Elsevier
Beta blockers have been used in the treatment of cardiovascular conditions for decades.
Despite a long history and status as a guideline-recommended treatment option for …

Nebivolol: impact on cardiac and endothelial function and clinical utility

JE Toblli, F DiGennaro, JF Giani… - Vascular Health and …, 2012 - Taylor & Francis
Endothelial dysfunction is a systemic pathological state of the endothelium characterized by
a reduction in the bioavailability of vasodilators, essentially nitric oxide, leading to impaired …

Nebivolol: A Highly Selective β1‐Adrenergic Receptor Blocker That Causes Vasodilation by Increasing Nitric Oxide

S Gupta, HM Wright - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

Effects of β-blocker selectivity on blood pressure variability and stroke: a systematic review

AJS Webb, U Fischer, PM Rothwell - Neurology, 2011 - AAN Enterprises
Objectives: β-Blockers increase variability in systolic blood pressure (SBP), which probably
explains their lesser effectiveness in preventing stroke vs myocardial infarction compared …

Nebivolol in the treatment of arterial hypertension

N Olawi, M Krüger, D Grimm, M Infanger… - Basic & Clinical …, 2019 - Wiley Online Library
This MiniReview reports the current knowledge about the treatment of arterial hypertension
with the third‐generation beta‐adrenoceptor antagonist (BAA) nebivolol. Furthermore, it …

Protective effects of nebivolol from oxidative stress to prevent hypertension-related target organ damage

A Coats, S Jain - Journal of human hypertension, 2017 - nature.com
Hypertension is one of the leading risk factors for morbidity and mortality in patients with
cardiovascular and cerebrovascular diseases and renal impairment. It also leads to target …

Nitric oxide mechanisms of nebivolol

A Maffei, G Lembo - Therapeutic advances in cardiovascular …, 2009 - journals.sagepub.com
β-blockers are among the most widely used drugs in the prevention and treatment of
cardiovascular disease, although they are associated with increased peripheral resistance …

Misconceptions and facts about beta-blockers

E Argulian, S Bangalore, FH Messerli - The American journal of medicine, 2019 - Elsevier
Beta-blockers are commonly used medications, and they have been traditionally considered
“cardioprotective.” Their clinical use appears to be more widespread than the available …

[HTML][HTML] Nebivolol: vasodilator properties and evidence for relevance in treatment of cardiovascular disease

JG Howlett - Canadian Journal of Cardiology, 2014 - Elsevier
Abstract β-adrenergic blocking agents, a pharmacologically diverse class of cardiovascular
medications, are recommended as first-line treatment for patients with hypertension and …