Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
plasticity, and increased neuronal responsiveness in central pain pathways after painful …
Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia
Opioids are a mainstay of acute pain management but can have many adverse effects,
contributing to problematic long-term use. Opioid tolerance (increased dose needed for …
contributing to problematic long-term use. Opioid tolerance (increased dose needed for …
Emerging targets in neuroinflammation-driven chronic pain
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …
and have limited success in controlling disease progression. Accumulating evidence …
[HTML][HTML] Cellular and molecular mechanisms of pain
AI Basbaum, DM Bautista, G Scherrer, D Julius - Cell, 2009 - cell.com
The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
[PDF][PDF] The α2δ-1-NMDA receptor complex is critically involved in neuropathic pain development and gabapentin therapeutic actions
Summary α2δ-1, commonly known as a voltage-activated Ca 2+ channel subunit, is a
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …
[HTML][HTML] Central sensitization: a generator of pain hypersensitivity by central neural plasticity
A Latremoliere, CJ Woolf - The journal of pain, 2009 - Elsevier
Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …
Regulating excitability of peripheral afferents: emerging ion channel targets
SG Waxman, GW Zamponi - Nature neuroscience, 2014 - nature.com
The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is
generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by …
generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by …
Emerging roles of resolvins in the resolution of inflammation and pain
Resolvins, including D and E series resolvins, are endogenous lipid mediators generated
during the resolution phase of acute inflammation from the omega-3 polyunsaturated fatty …
during the resolution phase of acute inflammation from the omega-3 polyunsaturated fatty …