Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Glucose dependency of cancer cells can be targeted with a high-fat, low-carbohydrate
ketogenic diet (KD). However, in IL-6-producing cancers, suppression of the hepatic …

In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in
individuals with non-small cell lung cancer. Key features of CAC include alterations in body …

B cells play a central role in humoral immunity but also have antibody-independent
functions. Studies to date have focused on B cells in blood and secondary lymphoid organs …

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …