Extracellular vesicles: novel mediators of cell communication in metabolic disease

I Huang-Doran, CY Zhang, A Vidal-Puig - Trends in Endocrinology & …, 2017 - cell.com
Metabolic homeostasis emerges from the complex, multidirectional crosstalk between key
metabolic tissues including adipose tissue, liver, and skeletal muscle. This crosstalk …

[HTML][HTML] Non-alcoholic fatty liver disease: An expanded review

M Benedict, X Zhang - World journal of hepatology, 2017 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) encompasses the simple steatosis to more
progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases …

Lipotoxic hepatocyte‐derived exosomal microRNA 192‐5p activates macrophages through rictor/Akt/forkhead box transcription factor O1 signaling in nonalcoholic …

XL Liu, Q Pan, HX Cao, FZ Xin, ZH Zhao, RX Yang… - …, 2020 - Wiley Online Library
Background and Aims Hepatic macrophages can be activated by many factors such as gut‐
derived bacterial components and factors released from damaged hepatocytes …

[HTML][HTML] Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells

YS Lee, SY Kim, E Ko, JH Lee, HS Yi, YJ Yoo, J Je… - Scientific Reports, 2017 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but
the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis …

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

A Rahmani, K Saleki, N Javanmehr… - Ageing research …, 2020 - Elsevier
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …

[HTML][HTML] Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance …

CJ Li, QH Fang, ML Liu, JN Lin - Theranostics, 2020 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) including exosomes, microvesicles (MVs), and apoptotic bodies,
are small membrane vesicular structures that are released during cell activation …

A high-fat diet attenuates AMPK α1 in adipocytes to induce exosome shedding and nonalcoholic fatty liver development in vivo

C Yan, X Tian, J Li, D Liu, D Ye, Z Xie, Y Han… - Diabetes, 2021 - Am Diabetes Assoc
Exosomes are important for intercellular communication, but the role of exosomes in the
communication between adipose tissue (AT) and the liver remains unknown. The aim of this …

[HTML][HTML] Extracellular vesicles as inflammatory drivers in NAFLD

AN Srinivas, D Suresh, PK Santhekadur… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease in most
parts of the world affecting one-third of the western population and a growing cause for end …

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

PB Devhare, RB Ray - Molecular aspects of medicine, 2018 - Elsevier
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are
released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids …

[HTML][HTML] Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …