The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

LA Díaz, JP Arab, A Louvet, R Bataller… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

Pathophysiological aspects of alcohol metabolism in the liver

J Hyun, J Han, C Lee, M Yoon, Y Jung - International journal of molecular …, 2021 - mdpi.com
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …

Microbiome-derived ethanol in nonalcoholic fatty liver disease

AS Meijnikman, M Davids, H Herrema, O Aydin… - Nature medicine, 2022 - nature.com
To test the hypothesis that the gut microbiota of individuals with nonalcoholic fatty liver
disease (NAFLD) produce enough ethanol to be a driving force in the development and …

Convergent somatic mutations in metabolism genes in chronic liver disease

SWK Ng, FJ Rouhani, SF Brunner, N Brzozowska… - Nature, 2021 - nature.com
The progression of chronic liver disease to hepatocellular carcinoma is caused by the
acquisition of somatic mutations that affect 20–30 cancer genes,,,,,,–. Burdens of somatic …

Gut microbiota and NAFLD: pathogenetic mechanisms, microbiota signatures, and therapeutic interventions

T Hrncir, L Hrncirova, M Kverka, R Hromadka… - Microorganisms, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Its
worldwide prevalence is rapidly increasing and is currently estimated at 24%. NAFLD is …

Non-alcoholic fatty liver disease and alcohol-related liver disease: two intertwined entities

F Idalsoaga, AV Kulkarni, OY Mousa, M Arrese… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide, with a prevalence of 25–30%. Since its first description in 1980, NAFLD has …

Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating …

G Sudhakaran, P Prathap, A Guru… - Molecular and cellular …, 2022 - Springer
Alcoholic liver disease is one of the most prominent liver diseases in the world. Lipid
accumulation accompanied by oxidative stress and inflammation in the liver is the most …

Severe hypertriglyceridemia: existing and emerging therapies

WA Malick, R Do, RS Rosenson - Pharmacology & Therapeutics, 2023 - Elsevier
Severe hypertriglyceridemia (sHTG), defined as a triglyceride (TG) concentration≥ 500
mg/dL (≥ 5.7 mmol/L) is an important risk factor for acute pancreatitis. Although lifestyle …

Understanding NAFLD: from case identification to interventions, outcomes, and future perspectives

D Clayton-Chubb, W Kemp, A Majeed, JS Lubel… - Nutrients, 2023 - mdpi.com
While non-alcoholic fatty liver disease (NAFLD) is a prevalent and frequent cause of liver-
related morbidity and mortality, it is also strongly associated with cardiovascular disease …

Effect of natural polysaccharides on alcoholic liver disease: A review

S Li, X Zhou, R Chen, Q Zhang, Y Sun… - International Journal of …, 2023 - Elsevier
In this study, we systematically collected relevant literature in the past five years on the
intervention of natural polysaccharides in alcoholic liver disease (ALD) and reviewed the …