Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

L Yang, A Li, Y Wang, Y Zhang - Signal transduction and targeted …, 2023 - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and …

Z Zhu, J Cai, W Hou, K Xu, X Wu, Y Song, C Bai… - Gut …, 2023 - Taylor & Francis
Although gut microbiota has been linked to cancer, little is known about the crosstalk
between gut-and intratumoral-microbiomes. The goal of this study was to determine whether …

[HTML][HTML] Intratumor microbiota in cancer pathogenesis and immunity: from mechanisms of action to therapeutic opportunities

M Wang, F Yu, P Li - Frontiers in Immunology, 2023 - frontiersin.org
Microbial species that dwell human bodies have profound effects on overall health and
multiple pathological conditions. The tumor microenvironment (TME) is characterized by …

Intratumoral microbiota: A new force in diagnosing and treating pancreatic cancer

Z Jiang, W Zhang, Z Zhang, G Sha, D Wang, D Tang - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is an increasingly growing source of cancer-related deaths and is often
diagnosed at advanced stages. Its treatment is difficult because of the poor results of …

[HTML][HTML] Therapeutic potential and limitations of curcumin as antimetastatic agent

P Dytrych, Z Kejík, J Hajduch, R Kaplánek… - Biomedicine & …, 2023 - Elsevier
Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Functions and mechanisms of lactylation in carcinogenesis and immunosuppression

J Su, Z Zheng, C Bian, S Chang, J Bao, H Yu… - Frontiers in …, 2023 - frontiersin.org
As critical executors regulating many cellular operations, proteins determine whether living
activities can be performed in an orderly and efficient manner. Precursor proteins are inert …

[HTML][HTML] Impact of gut microbiome in the development and treatment of pancreatic cancer: Newer insights

AI Bangolo, C Trivedi, I Jani, S Pender… - World Journal of …, 2023 - ncbi.nlm.nih.gov
The gut microbiome plays an important role in the variation of pharmacologic response. This
aspect is especially important in the era of precision medicine, where understanding how …

Intratumoral microbiome is driven by metastatic site and associated with immune histopathological parameters: An ancillary study of the SHIVA clinical trial

M Hilmi, M Kamal, S Vacher, C Dupain… - European Journal of …, 2023 - Elsevier
Background Data on the role of the microbiota in cancer have accumulated in recent years,
with particular interest in intratumoral bacteria. Previous results have shown that the …

Role of the intratumoral microbiome in tumor progression and therapeutics implications

YF Meng, ZY Fan, B Zhou, HX Zhan - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Microbes are widely present in various organs of the human body and play important roles
in numerous physiological and pathological processes. Nevertheless, owing to multiple …