Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant
kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of …

The global incidence of nonalcoholic fatty liver disease (NAFLD) has been surging in recent
years, however, no drug is currently approved to treat this disease. Quercetin, a natural …

As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …

Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

Inhibiting the activity of α-amylase has been considered an effective strategy to manage
hyperglycemia. Hyperoside and quercetin are the main natural flavonoids in various plants …

Ischemic stroke (IS) is characterized by high recurrence and disability; however, its therapies
are very limited. As one of the effective methods of treating acute attacks of IS, intravenous …

Ulcerative colitis (UC) pathogenesis is largely associated with intestinal epithelial barrier
dysfunction. A therapeutic approach to UC involves the repair of damaged intestinal barrier …

Background Different chemical toxicants or natural toxins can damage human health
through various routes such as air, water, fruits, foods, and vegetables. Purpose Herbal …