Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

Mental disorders are rapidly increasing each year and have become a major challenge
affecting the social and financial well-being of individuals. There is a need for phenotypic …

Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

Background: In patients attempting to discontinue their antidepressant medication, there
have been no prospective studies on patterns of withdrawal as a function of the rate of …

Background Antidepressant withdrawal symptoms may mimic symptoms of depression
relapse and can be challenging for patients when tapering or discontinuing antidepressants …

Antidepressant drugs are prescribed to patients with depressive, anxiety disorders, and
other conditions. Evidence about antidepressant discontinuation syndrome (ADS) and …

Introduction Mental health disorders, especially depressive and anxiety disorders, are
associated with substantial health-related burden. While the second-generation …

Pharmacotherapy is an effective treatment modality across psychiatric disorders.
Nevertheless, many patients discontinue their medication at some point. Evidence-based …

The presence of discontinuation symptoms when patients stop taking antidepressants has
sparked heated discussion, both on social media and in the general public press. In the …

Approximately half of the tens of millions of people currently taking antidepressants will
experience withdrawal symptoms when they try to reduce or come off them. Nearly half of …