The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours;
however, it remains unclear how genetically defined neurons in the DRN of a freely …

Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder.
However, the neural mechanisms that underlie sociability are poorly understood, limiting the …

To benefit from opportunities and cope with challenges in the environment, animals must
adapt their behavior to acquire rewards and to avoid punishments. Maladaptive changes in …

The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward
guided behavior as well as drug dependance, still remains elusive. Recently, novel methods …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

The cerebellum is involved in many motor, autonomic and cognitive functions, and new
tasks that have a cerebellar contribution are discovered on a regular basis. Simultaneously …

Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-
HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5 …