Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Natural dietary agents have attracted considerable attention due to their role in promoting
health and reducing the risk of diseases including cancer. Ginger, one of the most ancient …

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a
permanent cell cycle arrest. Senescent cells also secrete growth factors, proteases, and …

A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs
or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA …

Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and
progression. Vascular inflammation is associated with accelerated onset of late …

Maladaptive responses to stress adversely affect human behavior, yet the signaling
mechanisms underlying stress-responsive behaviors remain poorly understood. Using a …