wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

NJ Wheeler, KJ Gallo, EJG Rehborg… - PLOS Neglected …, 2022 - journals.plos.org
Advances in high-throughput and high-content imaging technologies require concomitant
development of analytical software capable of handling large datasets and generating …

Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms

KT Ryan, NJ Wheeler, IK Kamara… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Macrocyclic lactones are front-line therapies for parasitic roundworm infections; however,
there are no comprehensive studies on the activity of this drug class against parasitic …

Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans

EG Rehborg, NJ Wheeler… - PLOS Neglected Tropical …, 2023 - journals.plos.org
Parasitic nematodes infect billions of people and are mainly controlled by anthelmintic mass
drug administration (MDA). While there are growing efforts to better understand mechanisms …

Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target

KJ Gallo, NJ Wheeler, AM Elmi, PM Airs… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The diversification of anthelmintic targets and mechanisms of action will help ensure the
sustainable control of nematode infections in response to the growing threat of drug …

[PDF][PDF] TigerPrint s

T Brucei - 2023 - tigerprints.clemson.edu
The protozoan pathogen, Trypanosoma brucei, is the causative agent of sleeping sickness
in humans and nagana in livestock in sub-Saharan Africa. T. brucei cycles between tsetse fly …