The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a
marked impact on the wellbeing and productivity of individuals and has a major economic …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Purpose: Lens epithelial cell (LEC) conversion to myofibroblast is responsible for fibrotic
cataract surgery complications including posterior capsular opacification. While transforming …

Purpose Since the exact development of posterior subcapsular cataracts (PSCs) is poorly
understood, we review various risk factors and propose a two-stage etiology for PSCs …

Fibroblast growth factor (FGF) and transforming growth factor-beta (TGF-β) can regulate
and/or dysregulate lens epithelial cell (LEC) behaviour, including proliferation, fibre …

Lens epithelial explants are comprised of lens epithelial cells cultured in vitro on their native
basement membrane, the lens capsule. Biologists have used lens epithelial explants to …

Elucidation of both the molecular composition and organization of the ocular lens is a
prerequisite to understand its development, function, pathology, regenerative capacity, as …

Background Long noncoding RNA potassium voltage-gated channel subfamily Q member 1
opposite strand/antisense transcript 1 (KCNQ1OT1) takes part in diabetic cataract …

Epithelial–mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose
their cell‐to‐cell connection and are detached from the base membrane. EMT is …