Background This systematic review evaluated St. John's wort (SJW) for the treatment of
Major Depressive Disorder (MDD). The objectives of this review are to (1) evaluate the …

Although reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and
hydroxyl radical are generated as the natural byproduct of normal oxygen metabolism, they …

The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad
spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as …

Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest
used and most extensively investigated medicinal herbs. The medicinal form comprises the …

Ethnopharmacological relevance Herb–drug interactions are of great concern in health
practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all …

Ethnopharmacological relevance Hypericum perforatum L.(Hypericaceae), popularly called
St. John's wort (SJW), has a rich historical background being one of the oldest used and …

Depression is a major mental disease that is ranked as the fourth leading cause of disability.
In order to avoid unwanted adverse reactions, as well as improve efficacy, current …

Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I
biotransformation. The most important role in biotransformation belongs to CYP3A4 …

ABSTRACT Introduction: St. John's wort (SJW) is a common medicinal herb used for the
treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW …

In this paper we review the mechanisms of the antitumor effects of Hypericum perforatum
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …