Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Bacterial keratitis is a common corneal infection that is treated with topical antimicrobials. By
the time of presentation there may already be severe visual loss from corneal ulceration and …

Replication origins, fragile sites, and rDNA have been implicated as sources of
chromosomal instability. However, the defining genomic features of replication origins and …

With recent advances in high-throughput next-generation sequencing, it is possible to
describe the regulation and expression of genes at multiple levels. An assay for transposase …

Background The emergence of high throughput technologies that produce vast amounts of
genomic data, such as next-generation sequencing (NGS) is transforming biological …

As chromatin accessibility data from ATAC-seq experiments continues to expand, there is
continuing need for standardized analysis pipelines. Here, we present PEPATAC, an ATAC …

Since the advent of systems and synthetic biology, many studies have sought to harness
microbes as cell factories through genetic and metabolic engineering approaches. Yeast …

The processes that control where higher eukaryotic cells initiate DNA replication throughout
the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates …

ATAC‐seq, the assay for transposase‐accessible chromatin using sequencing, is a quick
and efficient approach to investigating the chromatin accessibility landscape. Investigating …

Enhancers are cis-acting sequences that regulate transcription rates of their target genes in
a cell-specific manner and harbor disease-associated sequence variants in cognate cell …