Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse

H Koike, MP Demars, JA Short, EM Nabel… - …, 2016 - nature.com
Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains
limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) …

A viral receptor complementation strategy to overcome CAV-2 tropism for efficient retrograde targeting of neurons

SJ Li, A Vaughan, JF Sturgill, A Kepecs - Neuron, 2018 - cell.com
Retrogradely transported neurotropic viruses enable genetic access to neurons based on
their long-range projections and have become indispensable tools for linking neural …

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats

L Boekhoudt, A Omrani, MCM Luijendijk… - European …, 2016 - Elsevier
Hyperactivity is a core symptom in various psychiatric disorders, including attention-
deficit/hyperactivity disorder, schizophrenia, bipolar disorders, and anorexia nervosa …

Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats

JM Bossert, S Adhikary, R St. Laurent, NJ Marchant… - …, 2016 - Springer
Rationale and objective In humans, exposure to contexts previously associated with heroin
use can provoke relapse. In rats, exposure to heroin-paired contexts after extinction of drug …

The role of mesolimbic reward neurocircuitry in prevention and rescue of the activity-based anorexia (ABA) phenotype in rats

CJ Foldi, LK Milton, BJ Oldfield - Neuropsychopharmacology, 2017 - nature.com
Patients suffering from anorexia nervosa (AN) become anhedonic; unable or unwilling to
derive normal pleasures and avoid rewarding outcomes, most profoundly in food intake. The …

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

JPH Verharen, JW De Jong, TJM Roelofs… - Nature …, 2018 - nature.com
Hyperdopaminergic states in mental disorders are associated with disruptive deficits in
decision making. However, the precise contribution of topographically distinct …

Temporally specific roles of ventral tegmental area projections to the nucleus accumbens and prefrontal cortex in attention and impulse control

JP Flores-Dourojeanni, C van Rijt… - Journal of …, 2021 - Soc Neuroscience
Deficits in impulse control and attention are prominent in the symptomatology of mental
disorders such as attention deficit hyperactivity disorder (ADHD), substance addiction …

Melanocortin 3 receptor signaling in midbrain dopamine neurons increases the motivation for food reward

R Pandit, A Omrani, M Luijendijk… - …, 2016 - nature.com
The central melanocortin (MC) system mediates its effects on food intake via MC3 (MC3R)
and MC4 receptors (MC4R). Although the role of MC4R in meal size determination …

Long‐term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy

J Desloovere, P Boon, LE Larsen, C Merckx… - …, 2019 - Wiley Online Library
Objective More than one‐third of patients with temporal lobe epilepsy (TLE) continue to have
seizures despite treatment with antiepileptic drugs, and many experience severe drug …

Identification of novel neurocircuitry through which leptin targets multiple inputs to the dopamine system to reduce food reward seeking

A Omrani, VAJ de Vrind, B Lodder, I Stoltenborg… - Biological …, 2021 - Elsevier
Background Leptin reduces the motivation to obtain food by modulating activity of the
mesolimbic dopamine (DA) system upon presentation of cues that predict a food reward …