Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …