Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Critical appraisal of recent translational chronopharmacology and chronotherapeutic reviews, meta-analyses, and pragmatic patient trials discloses significant …
RC Hermida, MH Smolensky, A Mojón… - Chronobiology …, 2023 - Taylor & Francis
The conduct of molecular and laboratory animal circadian rhythm research has increased
exponentially in the past few decades, such that today investigations are being performed by …
exponentially in the past few decades, such that today investigations are being performed by …
Lowering nighttime blood pressure with bedtime dosing of antihypertensive medications: controversies in hypertension-con side of the argument
Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications:
Controversies in Hypertension - Con Side of the Argument | Hypertension Science Volunteer …
Controversies in Hypertension - Con Side of the Argument | Hypertension Science Volunteer …
The effect of bedtime versus morning dosing of antihypertensive drugs on the cardiovascular outcomes: a systematic review and meta-analysis of randomized …
M Abuelazm, O Saleh, MM Albarakat… - Journal of …, 2023 - journals.lww.com
Methods: We synthesized randomized controlled studies (RCTs) from the Web of Science,
SCOPUS, EMBASE, PubMed, and CENTRAL until 13 October 2022. The risk ratio (RR) for …
SCOPUS, EMBASE, PubMed, and CENTRAL until 13 October 2022. The risk ratio (RR) for …
Circadian rhythms of risk factors and management in atherosclerotic and hypertensive vascular disease: Modern chronobiological perspectives of an ancient disease
YJ Geng, MH Smolensky, O Sum-Ping… - Chronobiology …, 2023 - Taylor & Francis
Atherosclerosis, a chronic inflammatory disease of the arteries that appears to have been as
prevalent in ancient as in modern civilizations, is predisposing to life-threatening and life …
prevalent in ancient as in modern civilizations, is predisposing to life-threatening and life …
Ingestion-time differences in the pharmacodynamics of dual-combination hypertension therapies: Systematic review and meta-analysis of published human trials
RG Hermida-Ayala, A Mojon… - Chronobiology …, 2022 - Taylor & Francis
The pharmacodynamics of hypertension medications can be significantly affected by
circadian rhythms in the biological mechanisms of the 24 h blood pressure (BP) pattern …
circadian rhythms in the biological mechanisms of the 24 h blood pressure (BP) pattern …
Systematic review and quality evaluation of published human ingestion-time trials of blood pressure-lowering medications and their combinations
RC Hermida, RG Hermida-Ayala, A Mojon… - Chronobiology …, 2021 - Taylor & Francis
ABSTRACT The pharmacokinetics (PK)–absorption, distribution, metabolism, and
elimination–and pharmacodynamics (PD) of hypertension medications can be significantly …
elimination–and pharmacodynamics (PD) of hypertension medications can be significantly …
[HTML][HTML] Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling
J Cortés-Ríos, M Rodriguez-Fernandez - Frontiers in Endocrinology, 2023 - frontiersin.org
Chronopharmacology of arterial hypertension impacts the long-term cardiovascular risk of
hypertensive subjects. Therefore, clinical and computational studies have proposed …
hypertensive subjects. Therefore, clinical and computational studies have proposed …
Understanding circadian mechanisms of sudden cardiac death: A report from the national heart, lung, and blood institute workshop, part 2: Population and clinical …
Sudden cardiac death (SCD) is the sudden, unexpected death due to abrupt loss of heart
function secondary to cardiovascular disease. In certain populations living with …
function secondary to cardiovascular disease. In certain populations living with …
[HTML][HTML] Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
ID Festus, J Spilberg, ME Young, S Cain… - Trends in Endocrinology …, 2024 - cell.com
Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves
cardiovascular care by aligning treatments with our body's daily rhythms and their …
cardiovascular care by aligning treatments with our body's daily rhythms and their …