Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …

Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …

Background FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of
the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest …

Major depressive disorder (MDD) is a chronic disease whose neurological basis and
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

Abstract Introduction Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-
adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment …

Stress during early life can impact the developing brain and increase vulnerability to mood
disorders later in life. Here, we argue that epigenetic mechanisms can mediate the gene …