[HTML][HTML] Reactive astrocytes as therapeutic targets for CNS disorders
ME Hamby, MV Sofroniew - Neurotherapeutics, 2010 - Elsevier
Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …
An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy
MJ Millan - Neuropharmacology, 2013 - Elsevier
Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …
development of the brain, leading to deficits in language, cognition, motor behaviour and …
[HTML][HTML] Epigenetics of early child development
C Murgatroyd, D Spengler - Frontiers in psychiatry, 2011 - frontiersin.org
Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …
impact the developing brain and increase vulnerability to mood disorders later in life. During …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Epigenetic alterations in depression and antidepressant treatment
Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …
in gene expression, ultimately influencing protein levels. Recent research indicates that …
[HTML][HTML] Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans
NC Gassen, J Hartmann, J Zschocke, J Stepan… - PLoS …, 2014 - journals.plos.org
Background FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of
the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest …
the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest …
[HTML][HTML] Epigenetic modifications of major depressive disorder
Major depressive disorder (MDD) is a chronic disease whose neurological basis and
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …
Neuroactive steroids, neurosteroidogenesis and sex
S Giatti, LM Garcia-Segura, GE Barreto… - Progress in …, 2019 - Elsevier
The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …
that target neurons and glial cells. They include hormonal steroids originated in the …
Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression
Abstract Introduction Altered DNA methylation (DNAm) levels of hypothalamic-pituitary-
adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment …
adrenal (HPA) axis genes has been associated with exposure to childhood maltreatment …
Epigenetic programming of the HPA axis: early life decides
C Murgatroyd, D Spengler - Stress, 2011 - Taylor & Francis
Stress during early life can impact the developing brain and increase vulnerability to mood
disorders later in life. Here, we argue that epigenetic mechanisms can mediate the gene …
disorders later in life. Here, we argue that epigenetic mechanisms can mediate the gene …