Insulin resistance is increasingly recognized as a chronic, low-level, inflammatory state.
Hyperinsulinemia and insulin action were initially proposed as the common preceding …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

Atherosclerosis is nowadays generally accepted as an inflammatory disease. It is known that
local inflammation occurs in the formation the plaques, as macrophages and other immuno …

In the last few years, there has been increasing interest in the physiological role of acylation-
stimulating protein (ASP). Recent studies in rats and mice, in particular in C3 (−/−) mice that …

The key concept of proteomics (looking at many proteins at once) opens new avenues in the
search for clinically useful biomarkers of disease, treatment response and ageing. As the …

Obesity, particularly central adiposity, is the primary causal factor in the development of
insulin resistance, the hallmark of the metabolic syndrome (MetS), a common condition …

Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and
glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides …

Cross-sectional studies have reported strong correlations between plasma levels of
complement C3, insulin, and glucose. This prospective study explored whether elevated …

Objective: Accumulation of visceral fat is recognized as a predictor of obesity‐related
metabolic disturbances. Factors that are predominantly expressed in this depot could …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …