WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …

Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD)
that often leads to fragility fracture, and its development is affected by multiple cellular …

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …

The extracellular matrix (ECM) is reported to be involved in tumorigenesis and progression.
Collagen IIX is a major ECM protein. Abnormal COL12A1 expression is associated with …

Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …

Tradeoffs centrally mediate the expression of human adaptations. We propose that tradeoffs
also influence the prevalence and forms of human maladaptation manifest in disease. By …

Wnt signalling pathways have key roles in joint development, homeostasis and disease,
particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating …