Recent advanced technologies for the characterization of xenobiotic-degrading microorganisms and microbial communities

S Mishra, Z Lin, S Pang, W Zhang, P Bhatt… - … in Bioengineering and …, 2021 - frontiersin.org
Global environmental contamination with a complex mixture of xenobiotics has become a
major environmental issue worldwide. Many xenobiotic compounds severely impact the …

Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system

M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Antimicrobial resistance: its surveillance, impact, and alternative management strategies in dairy animals

C Sharma, N Rokana, M Chandra, BP Singh… - Frontiers in veterinary …, 2018 - frontiersin.org
Antimicrobial resistance (AMR), one among the most common priority areas identified by
both national and international agencies, is mushrooming as a silent pandemic. The …

Exploring the potential of cell-free protein synthesis for extending the abilities of biological systems

K Khambhati, G Bhattacharjee, N Gohil… - … in bioengineering and …, 2019 - frontiersin.org
Cell-free protein synthesis (CFPS) system is a simple, rapid, and sensitive tool that is devoid
of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and …

Gene editing and systems biology tools for pesticide bioremediation: a review

S Jaiswal, DK Singh, P Shukla - Frontiers in microbiology, 2019 - frontiersin.org
Bioremediation is the degradation potential of microorganisms to dissimilate the complex
chemical compounds from the surrounding environment. The genetics and biochemistry of …

An insight into modern targeted genome-editing technologies with a special focus on CRISPR/Cas9 and its applications

F Akram, S Sahreen, F Aamir, I Haq, K Malik… - Molecular …, 2023 - Springer
Genome-editing technology has enabled scientists to make changes in model organisms'
DNA at the genomic level to get biotechnologically important products from them. Most …

Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications

G Bhattacharjee, N Gohil, K Khambhati, I Mani… - Journal of Controlled …, 2022 - Elsevier
A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …

Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens

K Khambhati, G Bhattacharjee, N Gohil… - Bioengineering & …, 2023 - Wiley Online Library
Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of
antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have …

Engineering strategies in microorganisms for the enhanced production of squalene: advances, challenges and opportunities

N Gohil, G Bhattacharjee, K Khambhati… - … in bioengineering and …, 2019 - frontiersin.org
The triterpene squalene is a natural compound that has demonstrated an extraordinary
diversity of uses in pharmaceutical, nutraceutical, and personal care industries. Emboldened …

[HTML][HTML] Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells

T Del'Guidice, JP Lepetit-Stoffaes, LJ Bordeleau… - PloS one, 2018 - journals.plos.org
Delivery of recombinant proteins to therapeutic cells is limited by a lack of efficient methods.
This hinders the use of transcription factors or Clustered Regularly Interspaced Short …