Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of
the auditory system. However, they are vulnerable to genetic defects, noise exposure …

Spiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner
ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to …

Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …

Spermidine is a naturally occurring polyamine compound that has many biological functions,
such as inducing autophagy and anti-inflammatory and anti-aging effects. Spermidine can …

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors, but its
side effects limit its application. Ototoxicity, a major adverse effect of cisplatin, causes …

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Aging is considered a contributing factor to many diseases such as cardiovascular disease,
Alzheimer's disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is …

Aging is associated with functional and morphological changes in the sensory organs,
including the auditory system. Mitophagy, a process that regulates the turnover of …

Hearing loss affects many people worldwide and occurs often as a result of age, ototoxic
drugs and/or excessive noise exposure. With a growing number of elderly people, the …

Dync1li1, a subunit of cytoplasmic dynein 1, is reported to play important roles in
intracellular retrograde transport in many tissues. However, the roles of Dync1li1 in the …