[HTML][HTML] mTOR signaling in the inner ear as potential target to treat hearing loss

M Cortada, S Levano, D Bodmer - International Journal of Molecular …, 2021 - mdpi.com
Hearing loss affects many people worldwide and occurs often as a result of age, ototoxic
drugs and/or excessive noise exposure. With a growing number of elderly people, the …

Reduced mitophagy in the cochlea of aged C57BL/6J mice

J Oh, CK Youn, Y Jun, ER Jo, SI Cho - Experimental Gerontology, 2020 - Elsevier
An increase in mitochondrial damage has been associated with a decline in the ability to
mitigate damage through mitophagy in age-related pathologies. The present study aimed to …

[HTML][HTML] Cellular autophagy, the compelling roles in hearing function and dysfunction

H Wan, Y Zhang, Q Hua - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Sensorineural hearing loss (SNHL) is currently a major health issue. As one of the most
common neurodegenerative diseases, SNHL is associated with the degradation of hair cells …

[HTML][HTML] Pre-exposure to lower-level noise mitigates cochlear synaptic loss induced by high-level noise

L Fan, Z Zhang, H Wang, C Li, Y Xing, S Yin… - Frontiers in systems …, 2020 - frontiersin.org
The auditory sensory organs appear to be less damaged by exposure to high-level noise
that is presented after exposure to non-traumatizing low-level noise. This phenomenon is …

Schisandrin B protect inner hair cells from cisplatin by inhibiting celluar oxidative stress and apoptosis

Y Li, Z Liu, J Chen, R Wang, X An, C Tian, H Yang… - Toxicology in Vitro, 2024 - Elsevier
Cisplatin is an effective chemotherapeutic agent; however, ototoxicity is one of its negative
effects that greatly limits the use of cisplatin in clinical settings. Previous research has shown …

[HTML][HTML] Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury

NB Gill, PD Dowker-Key, K Hubbard, BH Voy… - International Journal of …, 2023 - mdpi.com
By 2050, at least 700 million people will require hearing therapy while 2.5 billion are
projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the …

Potential role of modulating autophagy levels in sensorineural hearing loss

T Zou, R Xie, S Huang, D Lu, J Liu - Biochemical Pharmacology, 2024 - Elsevier
In recent years, extensive research has been conducted on the pathogenesis of
sensorineural hearing loss (SNHL). Apoptosis and necrosis have been identified to play …

[HTML][HTML] Sleep deprivation modifies noise-induced cochlear injury related to the stress hormone and autophagy in female mice

P Li, D Bing, S Wang, J Chen, Z Du, Y Sun… - Frontiers in …, 2019 - frontiersin.org
A lack of sleep is linked with a range of inner ear diseases, including hearing loss and
tinnitus. Here, we used a mouse model to investigate the effects of sleep deprivation (SD) on …

Association between oxidative balance score and hearing loss: a cross-sectional study from the NHANES database

Z Zhou, Y Han - Frontiers in Nutrition, 2024 - frontiersin.org
Aim The oxidative balance score (OBS), a composite score of dietary nutrients and lifestyles,
reflects an individual's oxidative and antioxidant status. Evidence showed that oxidative …

Low‐dose rapamycin‐induced autophagy in cochlear outer sulcus cells

C Saegusa, M Hosoya, T Nishiyama… - Laryngoscope …, 2020 - Wiley Online Library
Objectives Autophagy is an intracellular housekeeping process that degrades cytoplasmic
organelles, damaged molecules, and abnormal proteins or pathogens and is essential for …